If you follow number on Twitter is more than the number of people following you, you could harm your Twitter account’s SEO potential. Search engines “trust” those with more Twitter influence, and following many more people than follow you isn’t always an indicator of that say Marketing Profs/ You do the Maths.
Sad, vague, boring tweets are better kept to yourself. A little personality is fun. Questions and answers, statements and stats are all good content fillers for Twitter. See my week of Twitter Tricks post for more ideas. But for the most part, stay professional and positive. And always, always stay classy, of course!